Version 5.4
Mus musculus Protein: Tbc1d10a
Summary
InnateDB Protein IDBP-716629.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbc1d10a
Protein Name
Synonyms AI447804; EPI64; mFLJ00288; Tbc1d10;
Species Mus musculus
Ensembl Protein ENSMUSP00000136453
InnateDB Gene IDBG-142084 (Tbc1d10a)
Protein Structure
UniProt Annotation
Function Acts as GTPase-activating protein for RAB27A. {ECO:0000250}.
Subcellular Localization Cell projection, microvillus {ECO:0000250}. Note=Localizes to the microvilli-rich region of the syncytiotrophoblast. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in most tissues, except for skeletal muscle. {ECO:0000269PubMed:11285285}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005097 Rab GTPase activator activity
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005902 microvillus
Protein Structure and Domains
PDB ID MGI:2144164
InterPro IPR000195 Rab-GTPase-TBC domain
PFAM PF00566
PRINTS
PIRSF
SMART SM00164
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58802
PhosphoSite PhosphoSite-P58802
TrEMBL Q8K2U6
UniProt Splice Variant
Entrez Gene 103724
UniGene Mm.471313
RefSeq NP_598784
MGI ID
MGI Symbol Tbc1d10a
OMIM
CCDS CCDS56756
HPRD
IMGT
EMBL BC018300 BC029773
GenPept AAH18300 AAH29773

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca