InnateDB Protein
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IDBP-716729.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATF7
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Protein Name
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Synonyms
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ATFA;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000456858
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InnateDB Gene
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IDBG-37050 (ATF7)
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Protein Structure
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Function |
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.Isoform 4/ATF-A0 acts as a dominant repressor of the E- selectin/NF-ELAM1/delta-A promoter.Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00978, ECO:0000269PubMed:17264123}. Nucleus, nucleoplasm {ECO:0000269PubMed:17264123}. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.Isoform 5: Cytoplasm {ECO:0000269PubMed:21858082}.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta. {ECO:0000269PubMed:8288576}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
46
[view]
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Protein-Protein |
45
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
P17544
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PhosphoSite |
PhosphoSite-P17544
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11016
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UniGene |
Hs.620912
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RefSeq |
NP_001193612
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HUGO |
HGNC:792
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OMIM |
606371
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CCDS |
CCDS58238
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HPRD |
06968
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IMGT |
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EMBL |
AC023509
AC073594
AK298853
BC042363
BC136302
BC140006
CH471054
X52943
X57197
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GenPept |
AAH42363
AAI36303
AAI40007
BAG60976
CAA37118
CAA40483
EAW96723
EAW96724
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