InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zbed6

Summary

InnateDB Protein

IDBP-716774.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zbed6

Protein Name

Synonyms

1110003F06Rik; 5730454B08Rik; G630041M05Rik; mKIAA0663; Zc3hdc11a; Zc3hh11a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136026

InnateDB Gene

IDBG-705029 (Zbed6)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of other target genes containing the binding site. {ECO:0000269PubMed:20016685, ECO:0000269PubMed:20134481}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20016685}. Nucleus, nucleolus {ECO:0000269PubMed:20016685}. Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus. {ECO:0000269PubMed:20016685}.

Disease Associations

Tissue Specificity

Shows broad tissue distribution with expression detected in brain, stomach, intestine, heart, kidney, liver, lung, skeletal muscle, ovary, spleen, tail and testis. {ECO:0000269PubMed:20016685}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated