Version 5.4
Mus musculus Protein: Hist2h3c1
Summary
InnateDB Protein IDBP-716809.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hist2h3c1
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000134751
InnateDB Gene IDBG-706129 (Hist2h3c1)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0060968 regulation of gene silencing
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID MGI:2448355
InterPro IPR000164 Histone H3
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00125
PRINTS PR00622
PIRSF
SMART SM00428
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P84228
PhosphoSite PhosphoSite-P84228
TrEMBL B9EI85
UniProt Splice Variant
Entrez Gene 97114
UniGene Mm.422680
RefSeq NP_835734
MGI ID 2V88
MGI Symbol Hist2h3c1
OMIM
CCDS CCDS38554
HPRD
IMGT
EMBL AK010121 AK020421 AL590388 AY158941 AY158947 AY158948 AY158949 AY158950 AY158951 AY158954 AY158955 BC015270 BC094041 BC101954 BC101955 BC101956 BC103549 BC120800 BC120802 BC127042 BC132488 BC132490 BC139251 BC139252 CH466561 CH466620 M32459 M32461 M33989 U62669 U62671 U62674 U62675 X01685 X16148 X80328 Z30939
GenPept AAA37764 AAA37810 AAA37812 AAB04760 AAB04764 AAB04771 AAB04772 AAH15270 AAH94041 AAI01955 AAI01956 AAI01957 AAI03550 AAI20801 AAI20803 AAI27043 AAI32489 AAI32491 AAI39252 AAI39253 AAO06251 AAO06257 AAO06258 AAO06259 AAO06260 AAO06261 AAO06264 AAO06265 BAB26714 BAB32097 CAA25840 CAA34274 CAA56577 CAA83209 CAI25840 CAI25844 EDL32538 EDL32540 EDL32552 EDL32556 EDL32559 EDL38879 EDL38883

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca