Version 5.4
Mus musculus Protein: SLC25A37
Summary
InnateDB Protein IDBP-717003.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC25A37
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000135940
InnateDB Gene IDBG-703340 (SLC25A37)
Protein Structure
UniProt Annotation
Function Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme. {ECO:0000269PubMed:16511496}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in hematopoietic organs, fetal liver, bone marrow and spleen. {ECO:0000269PubMed:11845285, ECO:0000269PubMed:16511496}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005381 iron ion transmembrane transporter activity
Biological Process
GO:0034755 iron ion transmembrane transport
GO:0048250 mitochondrial iron ion transport
GO:0055072 iron ion homeostasis
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:5547785
InterPro IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain
PFAM PF00153
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q920G8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 100862085
UniGene
RefSeq XP_006519954
MGI ID
MGI Symbol Gm28049
OMIM
CCDS
HPRD
IMGT
EMBL AF288621 AF361699 AK015790 AK019700 AK021203 AK050414 AK086749
GenPept AAL23859 AAL27990 BAB29978 BAB31839 BAC25649 BAC34243 BAC39735

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca