InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DRD2

Summary

InnateDB Protein

IDBP-71702.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRD2

Protein Name

dopamine receptor D2

Synonyms

D2DR; D2R;

Species

Homo sapiens

Ensembl Protein

ENSP00000354859

InnateDB Gene

IDBG-71698 (DRD2)

Protein Structure

UniProt Annotation

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:21645528}; Multi-pass membrane protein {ECO:0000269PubMed:21645528}.

Disease Associations

Dystonia 11 (DYT11) [MIM:159900]: A myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. {ECO:0000269PubMed:10220438}. Note=The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic dystonia patients are rare, and their contribution to disease phenotype is unclear (PubMed:10716258). {ECO:0000269PubMed:10716258}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0015459	potassium channel regulator activity
GO:0035240	dopamine binding
GO:0035255	ionotropic glutamate receptor binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001659	temperature homeostasis
GO:0001666	response to hypoxia
GO:0001963	synaptic transmission, dopaminergic
GO:0001964	startle response
GO:0001975	response to amphetamine
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure
GO:0002027	regulation of heart rate
GO:0002028	regulation of sodium ion transport
GO:0002031	G-protein coupled receptor internalization
GO:0002052	positive regulation of neuroblast proliferation
GO:0002092	positive regulation of receptor internalization
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007270	neuron-neuron synaptic transmission
GO:0007409	axonogenesis
GO:0007416	synapse assembly
GO:0007608	sensory perception of smell
GO:0007616	long-term memory
GO:0007625	grooming behavior
GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0007631	feeding behavior
GO:0008104	protein localization
GO:0008285	negative regulation of cell proliferation
GO:0008306	associative learning
GO:0008542	visual learning
GO:0009416	response to light stimulus
GO:0009636	response to toxic substance
GO:0010039	response to iron ion
GO:0014059	regulation of dopamine secretion
GO:0014854	response to inactivity
GO:0016055	Wnt signaling pathway
GO:0021756	striatum development
GO:0021769	orbitofrontal cortex development
GO:0021853	cerebral cortex GABAergic interneuron migration
GO:0021984	adenohypophysis development
GO:0030336	negative regulation of cell migration
GO:0030432	peristalsis
GO:0030534	adult behavior
GO:0030814	regulation of cAMP metabolic process
GO:0030900	forebrain development
GO:0031223	auditory behavior
GO:0032147	activation of protein kinase activity
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0032467	positive regulation of cytokinesis
GO:0032922	circadian regulation of gene expression
GO:0033602	negative regulation of dopamine secretion
GO:0034776	response to histamine
GO:0035094	response to nicotine
GO:0035556	intracellular signal transduction
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0040018	positive regulation of multicellular organism growth
GO:0042220	response to cocaine
GO:0042321	negative regulation of circadian sleep/wake cycle, sleep
GO:0042417	dopamine metabolic process
GO:0042493	response to drug
GO:0043266	regulation of potassium ion transport
GO:0043278	response to morphine
GO:0043408	regulation of MAPK cascade
GO:0043473	pigmentation
GO:0043666	regulation of phosphoprotein phosphatase activity
GO:0045471	response to ethanol
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045776	negative regulation of blood pressure
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046488	phosphatidylinositol metabolic process
GO:0046676	negative regulation of insulin secretion
GO:0046717	acid secretion
GO:0048148	behavioral response to cocaine
GO:0048149	behavioral response to ethanol
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048678	response to axon injury
GO:0048755	branching morphogenesis of a nerve
GO:0050482	arachidonic acid secretion
GO:0050709	negative regulation of protein secretion
GO:0050804	regulation of synaptic transmission
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051584	regulation of dopamine uptake involved in synaptic transmission
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission
GO:0051823	regulation of synapse structural plasticity
GO:0051898	negative regulation of protein kinase B signaling
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060124	positive regulation of growth hormone secretion
GO:0060134	prepulse inhibition
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
GO:0060160	negative regulation of dopamine receptor signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090325	regulation of locomotion involved in locomotory behavior
GO:1900273	positive regulation of long-term synaptic potentiation
GO:1901386	negative regulation of voltage-gated calcium channel activity

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016328	lateral plasma membrane
GO:0030139	endocytic vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0030672	synaptic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0036126	sperm flagellum
GO:0043197	dendritic spine
GO:0043204	perikaryon
GO:0043679	axon terminus

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000929 Dopamine receptor family
IPR001922 Dopamine D2 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00242
PR00567

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P14416