InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PEG3

Summary

InnateDB Protein

IDBP-71722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEG3

Protein Name

zinc finger, imprinted 2

Synonyms

PW1; ZKSCAN22; ZNF904; ZSCAN24;

Species

Homo sapiens

Ensembl Protein

ENSP00000326581

InnateDB Gene

IDBG-71716 (PEG3)

Protein Structure

UniProt Annotation

Function

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. {ECO:0000250, ECO:0000269PubMed:11260267}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00187}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines. {ECO:0000269PubMed:11260267, ECO:0000269PubMed:11331620, ECO:0000269PubMed:9149948}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0010468	regulation of gene expression
GO:0035264	multicellular organism growth
GO:0071514	genetic imprinting