InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WDHD1

Summary

InnateDB Protein

IDBP-7173.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDHD1

Protein Name

WD repeat and HMG-box DNA binding protein 1

Synonyms

AND-1; CHTF4; CTF4;

Species

Homo sapiens

Ensembl Protein

ENSP00000353793

InnateDB Gene

IDBG-7169 (WDHD1)

Protein Structure

UniProt Annotation

Function

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. {ECO:0000269PubMed:19805216}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0070063	RNA polymerase binding

Biological Process

GO:0006396	RNA processing
GO:0033044	regulation of chromosome organization
GO:0070829	heterochromatin maintenance

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR009071 High mobility group box domain
IPR013979 Translation initiation factor, beta propellor-like domain
IPR017986 WD40-repeat-containing domain
IPR022100 Protein of unknown function DUF3639

PFAM

PF00400
PF00505
PF09011
PF08662
PF12341

PRINTS

PIRSF

SMART

SM00320
SM00398

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75717