InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Meis1

Summary

InnateDB Protein

IDBP-717403.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Meis1

Protein Name

Synonyms

C530044H18Rik; Evi8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000134969

InnateDB Gene

IDBG-152330 (Meis1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. {ECO:0000269PubMed:12183364, ECO:0000269PubMed:15882575}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:10082572, ECO:0000269PubMed:15882575}.

Disease Associations

Note=Meis1 serves as a site of viral integration in 15% of the tumors arising in BXH-2 mice that develop myeloid leukemia as a result of the expression of an ecotropic murine leukemia virus.

Tissue Specificity

Expressed at high levels in the lung with lower levels detected in the heart and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	25 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001525	angiogenesis
GO:0002089	lens morphogenesis in camera-type eye
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030097	hemopoiesis
GO:0035855	megakaryocyte development
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048514	blood vessel morphogenesis
GO:0060216	definitive hemopoiesis