InnateDB Protein
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IDBP-717714.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ndfip2
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Protein Name
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Synonyms
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0710001O20Rik; 2810436B12Rik; 9130207N19Rik; mKIAA1165; N4wbp5a;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000137875
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InnateDB Gene
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IDBG-185747 (Ndfip2)
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Protein Structure
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Function |
Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed, with highest levels in brain, liver, kidney and testis. {ECO:0000269PubMed:12050153}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
GO:0007165
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signal transduction
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GO:0010629
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negative regulation of gene expression
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GO:0031398
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positive regulation of protein ubiquitination
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GO:0032410
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negative regulation of transporter activity
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0051224
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negative regulation of protein transport
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Cellular Component |
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PDB ID |
MGI:1923523
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InterPro |
IPR019325
NEDD4/BSD2
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PFAM |
PF10176
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q91ZP6
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PhosphoSite |
PhosphoSite-Q91ZP6
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TrEMBL |
Q3V1V0
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UniProt Splice Variant |
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Entrez Gene |
76273
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UniGene |
Mm.474729
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RefSeq |
NP_083837
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MGI ID |
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MGI Symbol |
Ndfip2
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OMIM |
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CCDS |
CCDS49560
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HPRD |
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IMGT |
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EMBL |
AC113125
AC141878
AF411608
AK031073
AK049678
AK078939
AK132235
AK220371
BC071237
BC117075
BC119092
CH466544
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GenPept |
AAH71237
AAI17076
AAI19093
AAL05872
BAC27240
BAC33869
BAC37471
BAD90430
BAE21049
EDL00517
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