InnateDB Protein
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IDBP-71773.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ENDOV
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Protein Name
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endonuclease V
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000317810
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InnateDB Gene
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IDBG-71767 (ENDOV)
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Protein Structure
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Function |
Endoribonuclease that specifically cleaves inosine- containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'- UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures. {ECO:0000269PubMed:23139746, ECO:0000269PubMed:23912683, ECO:0000269PubMed:23912718}.
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Subcellular Localization |
Cytoplasm. Nucleus, nucleolus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000287
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magnesium ion binding
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GO:0003727
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single-stranded RNA binding
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GO:0004519
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endonuclease activity
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GO:0016888
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endodeoxyribonuclease activity, producing 5'-phosphomonoesters
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GO:0016891
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endoribonuclease activity, producing 5'-phosphomonoesters
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GO:0043566
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structure-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007581
Endonuclease V
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PFAM |
PF04493
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N8Q3
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PhosphoSite |
PhosphoSite-Q8N8Q3
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TrEMBL |
I3L0L4
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UniProt Splice Variant |
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Entrez Gene |
284131
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UniGene |
Hs.389678
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RefSeq |
NP_001158110
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HUGO |
HGNC:26640
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OMIM |
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CCDS |
CCDS54174
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HPRD |
08758
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IMGT |
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EMBL |
AC120024
AK092539
AK096344
AK096802
BC037889
BC045824
BC064545
CH471099
DQ500957
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GenPept |
AAH37889
AAH45824
AAH64545
ABF47100
BAC03912
BAC04765
EAW89605
EAW89607
EAW89615
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