InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZKSCAN4

Summary

InnateDB Protein

IDBP-71785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZKSCAN4

Protein Name

zinc finger with KRAB and SCAN domains 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366509

InnateDB Gene

IDBG-71783 (ZKSCAN4)

Protein Structure

UniProt Annotation

Function

May be involved in the transcriptional activation of MDM2 and EP300 genes. {ECO:0000269PubMed:17910948}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00187, ECO:0000269PubMed:17910948}.

Disease Associations

Tissue Specificity

Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine. {ECO:0000269PubMed:17910948}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001909 Krueppel-associated box
IPR003309 Transcription regulator SCAN
IPR007087 Zinc finger, C2H2
IPR008916 Retrovirus capsid, C-terminal
IPR015880 Zinc finger, C2H2-like

PFAM

PF01352
PF02023
PF00096

PRINTS

PIRSF

SMART

SM00349
SM00431
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q969J2