Version 5.4
Mus musculus Protein: Rsc1a1
Summary
InnateDB Protein IDBP-718287.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rsc1a1
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000136018
InnateDB Gene IDBG-202310 (Rsc1a1)
Protein Structure
UniProt Annotation
Function Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity). Regulates the expression of SLC5A1 in a tissue-specific manner and is specifically involved in its regulation in the small intestine. {ECO:0000250, ECO:0000269PubMed:15601832}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15601832}. Nucleus {ECO:0000269PubMed:15601832}. Golgi apparatus, trans- Golgi network {ECO:0000250}. Note=Localizes at the inner side of the plasma membrane.
Disease Associations
Tissue Specificity Expressed in epithelial and subepithelial cells of small intestine. {ECO:0000269PubMed:15601832}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0050892 intestinal absorption
GO:0051051 negative regulation of transport
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID MGI:1917244
InterPro IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
PFAM
PRINTS
PIRSF
SMART SM00165
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ER99
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 69994
UniGene
RefSeq
MGI ID
MGI Symbol Ddi2
OMIM
CCDS CCDS18879
HPRD
IMGT
EMBL AK006435 AL671733 BC031491 BC150752 CH466615 Y11917
GenPept AAI50753 BAB24588 CAA72676 CAM27071 EDL13393

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca