Version 5.4
Homo sapiens Protein: ZNF22
Summary
InnateDB Protein IDBP-71851.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF22
Protein Name zinc finger protein 22 (KOX 15)
Synonyms HKR-T1; KOX15; Zfp422; ZNF422;
Species Homo sapiens
Ensembl Protein ENSP00000298299
InnateDB Gene IDBG-71849 (ZNF22)
Protein Structure
UniProt Annotation
Function Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity In the embryo, expressed in developing craniofacial structures including dental epithelium of maxillary molar tooth organs, tongue epithelium and muscle, and craniofacial bone osteoblasts. In the adult, expressed in mesoderm-derived tissues such as skeletal muscle, heart, kidney and liver. Intermediate expression in spleen, thymus and brain. Low levels in endoderm-derived tissues such as intestine and colon. {ECO:0000269PubMed:14630903}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0042476 odontogenesis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P17026
PhosphoSite PhosphoSite-P17026
TrEMBL A0A024R7T4
UniProt Splice Variant
Entrez Gene 7570
UniGene Hs.667604
RefSeq NP_008894
HUGO HGNC:13012
OMIM 194529
CCDS CCDS7211
HPRD 01917
IMGT
EMBL AK291508 AL353801 AY137767 BC010642 BC041139 BC053687 BT009806 CH471160 M77172 S50223 X52346
GenPept AAA36815 AAB24264 AAH10642 AAH41139 AAH53687 AAN15804 AAP88808 BAF84197 CAA36572 CAI13068 EAW86632 EAW86633

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca