InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Exo5

Summary

InnateDB Protein

IDBP-718586.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Exo5

Protein Name

Synonyms

3110037I16Rik; AV297100; Dem1; Exo V; mExo5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136408

InnateDB Gene

IDBG-184087 (Exo5)

Protein Structure

UniProt Annotation

Function

Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Localizes to repair foci in response to DNA damage. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding