InnateDB Protein
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IDBP-71880.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHMP6
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Protein Name
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charged multivesicular body protein 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000317468
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InnateDB Gene
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IDBG-71878 (CHMP6)
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Protein Structure
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Function |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.
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Subcellular Localization |
Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane {ECO:0000305}. Note=Localizes to endosomal membranes.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:15511219}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005024
Snf7
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PFAM |
PF03357
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96FZ7
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PhosphoSite |
PhosphoSite-Q96FZ7
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TrEMBL |
I3L3E4
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UniProt Splice Variant |
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Entrez Gene |
79643
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UniGene |
Hs.514560
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RefSeq |
NP_078867
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HUGO |
HGNC:25675
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OMIM |
610901
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CCDS |
CCDS11774
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HPRD |
08564
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IMGT |
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EMBL |
AC127496
AK021811
AK223187
AK292105
AY329087
BC010108
CR457284
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GenPept |
AAH10108
AAQ91196
BAB13901
BAD96907
BAF84794
CAG33565
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