InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agrn

Summary

InnateDB Protein

IDBP-719100.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agrn

Protein Name

Synonyms

Agrin; nmf380;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137931

InnateDB Gene

IDBG-208363 (Agrn)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030548	acetylcholine receptor regulator activity
GO:0043236	laminin binding

Biological Process

GO:0007009	plasma membrane organization
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007528	neuromuscular junction development
GO:0008582	regulation of synaptic growth at neuromuscular junction
GO:0010469	regulation of receptor activity
GO:0043113	receptor clustering
GO:0043525	positive regulation of neuron apoptotic process
GO:0045213	neurotransmitter receptor metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:87961

InterPro

IPR000082 SEA domain
IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR002049 EGF-like, laminin
IPR002350 Kazal domain
IPR003645 Follistatin-like, N-terminal
IPR003884 Factor I / membrane attack complex
IPR004850 Agrin NtA
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

PFAM