Version 5.4
Mus musculus Protein: 2610002J02Rik
Summary
InnateDB Protein IDBP-719164.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol 2610002J02Rik
Protein Name
Synonyms Faap20;
Species Mus musculus
Ensembl Protein ENSMUSP00000137116
InnateDB Gene IDBG-207504 (2610002J02Rik)
Protein Structure
UniProt Annotation
Function Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0031593 polyubiquitin binding
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
GO:0070530 K63-linked polyubiquitin binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0019985 translesion synthesis
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0005694 chromosome
GO:0043240 Fanconi anaemia nuclear complex
Protein Structure and Domains
PDB ID MGI:1914763
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UN58
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 67513
UniGene Mm.10374
RefSeq NP_001177374
MGI ID
MGI Symbol 2610002J02Rik
OMIM
CCDS CCDS57317
HPRD
IMGT
EMBL AK144436 AL670413 BC117034 CA457860
GenPept AAI17035 BAE25889 CAM20052 CAO77979

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca