Version 5.4
Homo sapiens Protein: RUNX2
Summary
InnateDB Protein IDBP-719216.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RUNX2
Protein Name
Synonyms AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA;
Species Homo sapiens
Ensembl Protein ENSP00000458178
InnateDB Gene IDBG-89685 (RUNX2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 74 [view]
Protein-Protein 66 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005524 ATP binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
IPR008967 p53-like transcription factor, DNA-binding
IPR013524 Runt domain
PFAM PF00853
PRINTS PR00967
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL I3L0L0
UniProt Splice Variant
Entrez Gene 860
UniGene Hs.717834
RefSeq
HUGO HGNC:10472
OMIM 600211
CCDS
HPRD 02566
IMGT
EMBL AL096865 AL161907 AL358135 AL513219 AL589657
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca