InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSPB2-C11orf52

Summary

InnateDB Protein

IDBP-719263.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPB2-C11orf52

Protein Name

Synonyms

Hs.78846; HSP27; LOH11CR1K; MKBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000457706

InnateDB Gene

IDBG-543436 (HSPB2-C11orf52)

Protein Structure

UniProt Annotation

Function

May regulate the kinase DMPK. {ECO:0000269PubMed:9490724}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19464326}. Nucleus {ECO:0000269PubMed:19464326}. Note=Localizes to nuclear foci.

Disease Associations

Tissue Specificity

Expressed preferentially in skeletal muscle and heart but not in the lens.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity

Biological Process

GO:0006986	response to unfolded protein
GO:0043085	positive regulation of catalytic activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001436 Alpha crystallin/Heat shock protein
IPR002068 Alpha crystallin/Hsp20 domain
IPR008978 HSP20-like chaperone

PFAM

PF00011

PRINTS

PR00299

PIRSF

PIRSF036514

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16082

PhosphoSite

PhosphoSite-Q16082

TrEMBL

A8KAH6

UniProt Splice Variant

Entrez Gene

91894

UniGene

Hs.97013

RefSeq

HUGO

HGNC:41996

OMIM

602179

CCDS

CCDS8352

HPRD

IMGT

EMBL

AK293041 AY208910 BC109393 CH471065 CR457408 D89617 EF444955 EF444984 S67070 U75898

GenPept

AAB28816 AAB82757 AAI09394 AAO18081 ACA05948 ACA06000 BAA24004 BAF85730 CAG33689 EAW67168 EAW67169