InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AATK

Summary

InnateDB Protein

IDBP-72003.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AATK

Protein Name

apoptosis-associated tyrosine kinase

Synonyms

AATYK; AATYK1; LMR1; LMTK1; p35BP; PPP1R77;

Species

Homo sapiens

Ensembl Protein

ENSP00000324196

InnateDB Gene

IDBG-71999 (AATK)

Protein Structure

UniProt Annotation

Function

May be involved in neuronal differentiation. {ECO:0000269PubMed:10837911}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:10837911}. Cytoplasm, perinuclear region {ECO:0000269PubMed:10837911}. Note=Predominantly perinuclear.

Disease Associations

Tissue Specificity

Expressed in brain. {ECO:0000269PubMed:10837911}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007420	brain development
GO:0030517	negative regulation of axon extension
GO:0032482	Rab protein signal transduction
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0046777	protein autophosphorylation
GO:0051402	neuron apoptotic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0044295	axonal growth cone
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt