Version 5.4
Homo sapiens Protein: PRUNE2
Summary
InnateDB Protein IDBP-72048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRUNE2
Protein Name prune homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000365908
InnateDB Gene IDBG-72044 (PRUNE2)
Protein Structure
UniProt Annotation
Function May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269PubMed:16288218}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16288218}.
Disease Associations
Tissue Specificity A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. Expression is significantly higher in favorable tumors than aggressive ones. {ECO:0000269PubMed:16288218}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016462 pyrophosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001251 CRAL-TRIO domain
IPR004097 DHHA2 domain
IPR022181 Bcl2-/adenovirus E1B 19kDa-interacting protein 2
PFAM PF00650
PF13716
PF02833
PF12496
PRINTS
PIRSF
SMART SM00516
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WUY3
PhosphoSite PhosphoSite-Q8WUY3
TrEMBL
UniProt Splice Variant
Entrez Gene 158471
UniGene Hs.642477
RefSeq NP_056040
HUGO HGNC:25209
OMIM 610691
CCDS CCDS47982
HPRD 12970
IMGT
EMBL AB002365 AB050197 AK298805 AL161626 AL359314 AL390239 AY439213 AY439214 BC022571
GenPept AAH22571 AAR15150 AAR15151 BAA20822 BAD93351 BAG60940 CAI10915 CAI16084 CAI39749 CAI39750 CAQ68519 CAX14933

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca