InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NMI

Summary

InnateDB Protein

IDBP-72074.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NMI

Protein Name

N-myc (and STAT) interactor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000243346

InnateDB Gene

IDBG-72072 (NMI)

Protein Structure

UniProt Annotation

Function

May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0005515	protein binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006954	inflammatory response
GO:0007259	JAK-STAT cascade
GO:2001141	regulation of RNA biosynthetic process