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InnateDB Protein
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IDBP-72127.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRUNE2
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Protein Name
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prune homolog 2 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365903
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InnateDB Gene
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IDBG-72044 (PRUNE2)
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Protein Structure
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| Function |
May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. {ECO:0000269PubMed:16288218}.
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| Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16288218}.
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| Disease Associations |
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| Tissue Specificity |
A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. Expression is significantly higher in favorable tumors than aggressive ones. {ECO:0000269PubMed:16288218}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
13
[view]
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| Protein-Protein |
13
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
1 [view]
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q8WUY3
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| TrEMBL |
X6R9J3
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| UniProt Splice Variant |
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| Entrez Gene |
158471
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| UniGene |
Hs.642477
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| RefSeq |
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| HUGO |
HGNC:25209
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| OMIM |
610691
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| CCDS |
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| HPRD |
12970
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| IMGT |
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| EMBL |
AL161626
AL359314
AL390239
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| GenPept |
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Version 5.4