InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VHLL

Summary

InnateDB Protein

IDBP-721894.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VHLL

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000464258

InnateDB Gene

IDBG-103466 (VHLL)

Protein Structure

UniProt Annotation

Function

Functions as a dominant-negative VHL to serve as a protector of HIFalpha. {ECO:0000269PubMed:14757845}.

Subcellular Localization

Disease Associations

Tissue Specificity

Abundantly expressed in the placenta. {ECO:0000269PubMed:14757845}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0006355	regulation of transcription, DNA-templated
GO:0010498	proteasomal protein catabolic process
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process
GO:0030182	neuron differentiation
GO:0030198	extracellular matrix organization
GO:0042069	regulation of catecholamine metabolic process
GO:0043534	blood vessel endothelial cell migration
GO:0045471	response to ethanol
GO:0051291	protein heterooligomerization
GO:0070243	regulation of thymocyte apoptotic process
GO:0070244	negative regulation of thymocyte apoptotic process
GO:2001233	regulation of apoptotic signaling pathway