InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ercc1

Summary

InnateDB Protein

IDBP-722524.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ercc1

Protein Name

Synonyms

Ercc-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135767

InnateDB Gene

IDBG-150201 (Ercc1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001094	TFIID-class transcription factor binding
GO:0003684	damaged DNA binding
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0017025	TBP-class protein binding

Biological Process

GO:0000720	pyrimidine dimer repair by nucleotide-excision repair
GO:0001302	replicative cell aging
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006949	syncytium formation
GO:0006974	cellular response to DNA damage stimulus
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008584	male gonad development
GO:0009650	UV protection
GO:0010165	response to X-ray
GO:0010259	multicellular organismal aging
GO:0035166	post-embryonic hemopoiesis
GO:0035264	multicellular organism growth
GO:0036297	interstrand cross-link repair
GO:0045190	isotype switching
GO:0048468	cell development
GO:0048477	oogenesis
GO:0051276	chromosome organization
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex

Protein Structure and Domains

PDB ID

MGI:95412

InterPro

IPR004579 DNA repair protein rad10
IPR011335 Restriction endonuclease type II-like

PFAM

PF03834

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

H3BLF5

UniProt Splice Variant

Entrez Gene

13870

UniGene

Mm.280913

RefSeq

MGI ID

MGI Symbol

Ercc1

OMIM

CCDS

HPRD

IMGT

EMBL

AC148988

GenPept