InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPLOC4

Summary

InnateDB Protein

IDBP-72368.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPLOC4

Protein Name

nuclear protein localization 4 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000331487

InnateDB Gene

IDBG-72366 (NPLOC4)

Protein Structure

UniProt Annotation

Function

The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with the endoplasmic reticulum and nuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver. {ECO:0000269PubMed:11574150}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	91 [view]
Protein-Protein	90 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007030	Golgi organization
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0061025	membrane fusion

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network

Protein Structure and Domains

PDB ID

InterPro

IPR001876 Zinc finger, RanBP2-type
IPR007716 NPL4, zinc-binding putative
IPR007717 Nuclear pore localisation protein NPL4
IPR016563 Polyubiquitin-tagged protein recognition complex, Npl4 component
IPR024682 Nuclear pore localisation protein Npl4, ubiquitin-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00641
PF05020
PF05021
PF11543

PRINTS

PIRSF

PIRSF010052

SMART

SM00547

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt