InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FMNL2

Summary

InnateDB Protein

IDBP-72474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FMNL2

Protein Name

formin-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000288670

InnateDB Gene

IDBG-72470 (FMNL2)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics. {ECO:0000269PubMed:21834987}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005488	binding
GO:0017048	Rho GTPase binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0016043	cellular component organization
GO:0022604	regulation of cell morphogenesis
GO:0030036	actin cytoskeleton organization
GO:0030866	cortical actin cytoskeleton organization

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR010472 Formin, FH3 domain
IPR010473 Formin, GTPase-binding domain
IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold
IPR017987 Wilm\'s tumour protein

PFAM

PF06367
PF06371
PF02181

PRINTS

PR00049

PIRSF

SMART

SM00498

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt