Version 5.4
Mus musculus Protein: Ttc28
Summary
InnateDB Protein IDBP-724913.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttc28
Protein Name
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000137609
InnateDB Gene IDBG-190708 (Ttc28)
Protein Structure
UniProt Annotation
Function During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. {ECO:0000250}.Essential for the formation and integrity of the midbody. Max play a critical role in the progress of mitosis and cytokinesis during cell cycle (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}. Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in embryos at all stages examined. In adult tissues, detected in heart and at low levels in kidney and testis. {ECO:0000269PubMed:23036704}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0007346 regulation of mitotic cell cycle
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0030496 midbody
GO:0072686 mitotic spindle
GO:0097431 mitotic spindle pole
GO:1990023 mitotic spindle midzone
Protein Structure and Domains
PDB ID MGI:2140873
InterPro IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat
PFAM PF00515
PF07719
PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80XJ3
PhosphoSite PhosphoSite-Q80XJ3
TrEMBL
UniProt Splice Variant
Entrez Gene 209683
UniGene Mm.398868
RefSeq NP_001254551
MGI ID
MGI Symbol Ttc28
OMIM
CCDS CCDS59682
HPRD
IMGT
EMBL AC121934 AC122226 AC124425 AC147632 AC155173 AK031458 AK081382 AK122427 BC046779 BC060735
GenPept AAH46779 AAH60735 BAC27414 BAC38208 BAC65709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca