InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOA4

Summary

InnateDB Protein

IDBP-72501.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOA4

Protein Name

apolipoprotein A-IV

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000350425

InnateDB Gene

IDBG-72499 (APOA4)

Protein Structure

UniProt Annotation

Function

May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Synthesized primarily in the intestine and secreted in plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005319	lipid transporter activity
GO:0005507	copper ion binding
GO:0008289	lipid binding
GO:0016209	antioxidant activity
GO:0017127	cholesterol transporter activity
GO:0031210	phosphatidylcholine binding
GO:0042803	protein homodimerization activity
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0002227	innate immune response in mucosa
GO:0006869	lipid transport
GO:0006982	response to lipid hydroperoxide
GO:0007159	leukocyte cell-cell adhesion
GO:0007603	phototransduction, visible light
GO:0008203	cholesterol metabolic process
GO:0010873	positive regulation of cholesterol esterification
GO:0010898	positive regulation of triglyceride catabolic process
GO:0019430	removal of superoxide radicals
GO:0030300	regulation of intestinal cholesterol absorption
GO:0032374	regulation of cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034371	chylomicron remodeling
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034378	chylomicron assembly
GO:0034445	negative regulation of plasma lipoprotein particle oxidation
GO:0035634	response to stilbenoid
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0042744	hydrogen peroxide catabolic process
GO:0043691	reverse cholesterol transport
GO:0044240	multicellular organismal lipid catabolic process
GO:0044281	small molecule metabolic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0046470	phosphatidylcholine metabolic process
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0055088	lipid homeostasis
GO:0065005	protein-lipid complex assembly

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005788	endoplasmic reticulum lumen
GO:0005829	cytosol
GO:0009986	cell surface
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle