Version 5.4
Homo sapiens Protein: TWSG1
Summary
InnateDB Protein IDBP-725548.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TWSG1
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000463331
InnateDB Gene IDBG-759 (TWSG1)
Protein Structure
UniProt Annotation
Function May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9GZX9
PhosphoSite PhosphoSite-Q9GZX9
TrEMBL
UniProt Splice Variant
Entrez Gene 57045
UniGene Hs.603728
RefSeq
HUGO HGNC:12429
OMIM 605049
CCDS
HPRD 05443
IMGT
EMBL AF196834 AF294628 AJ297391 AK027629 AK075550 AK315751 AP001033 BC020490 CH471113
GenPept AAG10076 AAG43468 AAH20490 BAB55246 BAC11693 BAG38105 CAC05581 EAX01606 EAX01607

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca