Version 5.4
Homo sapiens Protein: RPRM
Summary
InnateDB Protein IDBP-72660.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPRM
Protein Name reprimo, TP53 dependent G2 arrest mediator candidate
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000314946
InnateDB Gene IDBG-72658 (RPRM)
Protein Structure
UniProt Annotation
Function May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007050 cell cycle arrest
GO:0007346 regulation of mitotic cell cycle
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NS64
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56475
UniGene Hs.100890
RefSeq NP_062819
HUGO HGNC:24201
OMIM 612171
CCDS CCDS2198
HPRD 18002
IMGT
EMBL AB043585 AC012501 AK074808 AK311958 BC002908 CH471058
GenPept AAH02908 AAY14783 BAB01513 BAG34898 BAG52007 EAX11467

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca