InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TLE4

Summary

InnateDB Protein

IDBP-72743.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLE4

Protein Name

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

Synonyms

BCE-1; BCE1; E(spI); ESG; ESG4; GRG4;

Species

Homo sapiens

Ensembl Protein

ENSP00000365720

InnateDB Gene

IDBG-72733 (TLE4)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

In all tissues examined, mostly in brain, and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003682	chromatin binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0008150	biological_process
GO:0016055	Wnt signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR005617 Groucho/TLE, N-terminal Q-rich domain
IPR009146 Groucho/transducin-like enhancer
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF03920

PRINTS

PR01850

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt