InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC16A8

Summary

InnateDB Protein

IDBP-7275.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC16A8

Protein Name

solute carrier family 16, member 8 (monocarboxylic acid transporter 3)

Synonyms

MCT3; REMP;

Species

Homo sapiens

Ensembl Protein

ENSP00000321735

InnateDB Gene

IDBG-7273 (SLC16A8)

Protein Structure

UniProt Annotation

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Retinal pigment epithelium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015129	lactate transmembrane transporter activity
GO:0015293	symporter activity
GO:0015355	secondary active monocarboxylate transmembrane transporter activity

Biological Process

GO:0006090	pyruvate metabolic process
GO:0007596	blood coagulation
GO:0015711	organic anion transport
GO:0015727	lactate transport
GO:0035873	lactate transmembrane transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0050900	leukocyte migration
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004743 Monocarboxylate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95907

PhosphoSite