InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLGAP5

Summary

InnateDB Protein

IDBP-7283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLGAP5

Protein Name

discs, large (Drosophila) homolog-associated protein 5

Synonyms

DLG7; HURP;

Species

Homo sapiens

Ensembl Protein

ENSP00000247191

InnateDB Gene

IDBG-7279 (DLGAP5)

Protein Structure

UniProt Annotation

Function

Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. {ECO:0000269PubMed:12527899, ECO:0000269PubMed:14699157, ECO:0000269PubMed:15145941}.

Subcellular Localization

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.

Disease Associations

Tissue Specificity

Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. {ECO:0000269PubMed:12527899}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding

Biological Process

GO:0000087	mitotic M phase
GO:0007079	mitotic chromosome movement towards spindle pole
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0016311	dephosphorylation
GO:0045842	positive regulation of mitotic metaphase/anaphase transition