Version 5.4
Homo sapiens Protein: FAAH2
Summary
InnateDB Protein IDBP-72861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAAH2
Protein Name fatty acid amide hydrolase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364035
InnateDB Gene IDBG-72859 (FAAH2)
Protein Structure
UniProt Annotation
Function Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. {ECO:0000269PubMed:17015445}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in the brain, small intestine and testis. Also expressed in the heart, kidney, liver, lung and prostate. {ECO:0000269PubMed:17015445}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000120 Amidase
IPR023631 Amidase signature domain
PFAM PF01425
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6GMR7
PhosphoSite PhosphoSite-Q6GMR7
TrEMBL B2C6G4
UniProt Splice Variant
Entrez Gene 158584
UniGene Hs.731245
RefSeq NP_777572
HUGO HGNC:26440
OMIM 300654
CCDS CCDS14375
HPRD 06551
IMGT
EMBL AK055766 AL590394 AL606754 AL928898 BC048279 BC073922 CH471154 EU285560 Z83745
GenPept AAH48279 AAH73922 ABZ79724 BAB71007 CAH71179 CAI40731 CAI40852 CAI42802 EAW93245

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca