InnateDB Protein
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IDBP-73035.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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STRA13
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Protein Name
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stimulated by retinoic acid 13 homolog (mouse)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000302951
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InnateDB Gene
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IDBG-73033 (STRA13)
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Protein Structure
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Function |
DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. {ECO:0000269PubMed:19620631, ECO:0000269Ref.5, ECO:0000269Ref.6}.
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Subcellular Localization |
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018552
Centromere protein X
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PFAM |
PF09415
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A8MT69
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PhosphoSite |
PhosphoSite-A8MT69
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
201254
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UniGene |
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RefSeq |
NP_659435
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HUGO |
HGNC:11422
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OMIM |
615128
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CCDS |
CCDS32772
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HPRD |
18121
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IMGT |
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EMBL |
AC137723
BC009571
BC011610
U95006
U95007
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GenPept |
AAB53638
AAB53639
AAH09571
AAH11610
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