Version 5.4
Homo sapiens Protein: ARHGEF9
Summary
InnateDB Protein IDBP-73049.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF9
Protein Name Cdc42 guanine nucleotide exchange factor (GEF) 9
Synonyms COLLYBISTIN; EIEE8; HPEM-2; PEM-2; PEM2;
Species Homo sapiens
Ensembl Protein ENSP00000364004
InnateDB Gene IDBG-73041 (ARHGEF9)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0007268 synaptic transmission
GO:0032321 positive regulation of Rho GTPase activity
GO:0034220 ion transmembrane transport
GO:0035023 regulation of Rho protein signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0055085 transmembrane transport
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain
PFAM PF00621
PF00018
PF14604
PF00169
PF07653
PRINTS PR00452
PIRSF
SMART SM00325
SM00326
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43307
PhosphoSite PhosphoSite-O43307
TrEMBL
UniProt Splice Variant
Entrez Gene 23229
UniGene Hs.54697
RefSeq
HUGO HGNC:14561
OMIM 300429
CCDS
HPRD 02337
IMGT
EMBL AB007884 AK289993 AK295033 AL355142 AL391277 AL451106 BC056892 BC117406
GenPept AAI17407 BAA24854 BAF82682 BAG58088 CAI39550 CAI40401 CAI41195

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca