InnateDB Protein
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IDBP-73055.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PKP4
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Protein Name
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plakophilin 4
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Synonyms
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p0071;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000374409
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InnateDB Gene
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IDBG-73053 (PKP4)
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Protein Structure
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Function |
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269PubMed:17115030}.
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Subcellular Localization |
Cell junction, desmosome {ECO:0000269PubMed:17115030}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:17115030}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:17115030}. Midbody {ECO:0000269PubMed:17115030}. Cell membrane {ECO:0000269PubMed:17115030}; Peripheral membrane protein {ECO:0000269PubMed:17115030}. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
30
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000225
Armadillo
IPR016024
Armadillo-type fold
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PFAM |
PF00514
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PRINTS |
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PIRSF |
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SMART |
SM00185
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TIGRFAMs |
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Modification |
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SwissProt |
Q99569
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PhosphoSite |
PhosphoSite-Q99569
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TrEMBL |
Q53TM5
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UniProt Splice Variant |
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Entrez Gene |
8502
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UniGene |
Hs.407580
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RefSeq |
NP_003619
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HUGO |
HGNC:9026
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OMIM |
604276
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CCDS |
CCDS33305
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HPRD |
05043
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IMGT |
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EMBL |
AC005042
AC008070
BC050308
X81889
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GenPept |
AAH50308
AAY14929
CAA57478
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