InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PKP4

Summary

InnateDB Protein

IDBP-73057.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PKP4

Protein Name

plakophilin 4

Synonyms

p0071;

Species

Homo sapiens

Ensembl Protein

ENSP00000374407

InnateDB Gene

IDBG-73053 (PKP4)

Protein Structure

UniProt Annotation

Function

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. {ECO:0000269PubMed:17115030}.

Subcellular Localization

Cell junction, desmosome {ECO:0000269PubMed:17115030}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:17115030}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:17115030}. Midbody {ECO:0000269PubMed:17115030}. Cell membrane {ECO:0000269PubMed:17115030}; Peripheral membrane protein {ECO:0000269PubMed:17115030}. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0007043	cell-cell junction assembly
GO:0007267	cell-cell signaling
GO:0010628	positive regulation of gene expression
GO:0016337	single organismal cell-cell adhesion
GO:0030155	regulation of cell adhesion
GO:0032321	positive regulation of Rho GTPase activity
GO:0032467	positive regulation of cytokinesis

Cellular Component

GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009898	cytoplasmic side of plasma membrane
GO:0030057	desmosome
GO:0030496	midbody
GO:0044291	cell-cell contact zone
GO:0048471	perinuclear region of cytoplasm
GO:0051233	spindle midzone
GO:0072686	mitotic spindle