InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TLE1

Summary

InnateDB Protein

IDBP-73130.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLE1

Protein Name

transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

Synonyms

ESG; ESG1; GRG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000365682

InnateDB Gene

IDBG-73128 (TLE1)

Protein Structure

UniProt Annotation

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000269PubMed:10660609}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12397081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.

Disease Associations

Tissue Specificity

In all tissues examined, mostly in brain, liver and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 142 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	142 [view]
Protein-Protein	142 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0009887	organ morphogenesis
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045892	negative regulation of transcription, DNA-templated
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR005617 Groucho/TLE, N-terminal Q-rich domain
IPR009146 Groucho/transducin-like enhancer
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF03920

PRINTS

PR01850

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt