InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FASN

Summary

InnateDB Protein

IDBP-73239.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FASN

Protein Name

fatty acid synthase

Synonyms

FAS; OA-519; SDR27X1;

Species

Homo sapiens

Ensembl Protein

ENSP00000304592

InnateDB Gene

IDBG-73235 (FASN)

Protein Structure

UniProt Annotation

Function

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Ubiquitous. Prominent expression in brain, lung, and liver. {ECO:0000269PubMed:7567999, ECO:0000269PubMed:7595075}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004312	fatty acid synthase activity
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0016788	hydrolase activity, acting on ester bonds
GO:0031177	phosphopantetheine binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0047117	enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO:0070402	NADPH binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006084	acetyl-CoA metabolic process
GO:0006112	energy reserve metabolic process
GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0015939	pantothenate metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0031325	positive regulation of cellular metabolic process
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042470	melanosome
GO:0042587	glycogen granule
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001031 Thioesterase
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR009081 Acyl carrier protein-like
IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013216 Methyltransferase type 11
IPR013217 Methyltransferase type 12
IPR013968 Polyketide synthase, KR
IPR014030 Beta-ketoacyl synthase, N-terminal
IPR014031 Beta-ketoacyl synthase, C-terminal
IPR014043 Acyl transferase
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding
IPR016039 Thiolase-like
IPR020801 Polyketide synthase, acyl transferase domain
IPR020806 Polyketide synthase, phosphopantetheine-binding domain
IPR020807 Polyketide synthase, dehydratase domain
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain
IPR020842 Polyketide synthase/Fatty acid synthase, KR
IPR020843 Polyketide synthase, enoylreductase
IPR029058 Alpha/Beta hydrolase fold
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM