Version 5.4
Homo sapiens Protein: LAS1L
Summary
InnateDB Protein IDBP-73278.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAS1L
Protein Name LAS1-like (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000363940
InnateDB Gene IDBG-73274 (LAS1L)
Protein Structure
UniProt Annotation
Function Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269PubMed:20647540, ECO:0000269PubMed:22872859}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:20647540}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 29 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006364 rRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0016020 membrane
GO:0071339 MLL1 complex
Protein Structure and Domains
PDB ID
InterPro IPR007174 Las1-like
PFAM PF04031
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y4W2
PhosphoSite PhosphoSite-Q9Y4W2
TrEMBL B3KNR6
UniProt Splice Variant
Entrez Gene 81887
UniGene Hs.721716
RefSeq NP_001164120
HUGO HGNC:25726
OMIM
CCDS CCDS55434
HPRD 06519
IMGT
EMBL AF116730 AK022587 AK054817 AK074087 AK125760 AL050306 BC014545 BC018610 BC019302 DQ323624
GenPept AAH14545 AAH18610 AAH19302 AAO15306 ABD39127 BAB14114 BAB84913 BAG51428 BAG54243 CAB51351 CAI42835 CAI42836

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca