Version 5.4
Homo sapiens Protein: CD302
Summary
InnateDB Protein IDBP-73285.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD302
Protein Name CD302 molecule
Synonyms BIMLEC; CLEC13A; DCL-1; DCL1;
Species Homo sapiens
Ensembl Protein ENSP00000259053
InnateDB Gene IDBG-403891 (CD302)
Protein Structure
UniProt Annotation
Function Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. {ECO:0000269PubMed:17947679}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, filopodium {ECO:0000269PubMed:17947679}. Cytoplasm, cell cortex {ECO:0000269PubMed:17947679}. Cell projection, microvillus {ECO:0000269PubMed:17947679}. Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.
Disease Associations
Tissue Specificity Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed- Sternberg (HRS) cells. {ECO:0000269PubMed:12824192, ECO:0000269PubMed:17947679}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005529 sugar binding
GO:0030246 carbohydrate binding
Biological Process
GO:0006909 phagocytosis
Cellular Component
GO:0005902 microvillus
GO:0005938 cell cortex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030175 filopodium
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IX05
PhosphoSite PhosphoSite-Q8IX05
TrEMBL
UniProt Splice Variant
Entrez Gene 9936
UniGene Hs.682302
RefSeq NP_055695
HUGO HGNC:30843
OMIM 612246
CCDS CCDS33308
HPRD 09906
IMGT
EMBL AC009961 AF499000 AK291279 AK304422 AY314007 BC020646 D14664
GenPept AAH20646 AAN77050 AAP79900 AAY14942 BAA03498 BAF83968 BAG65251

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca