InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LY75

Summary

InnateDB Protein

IDBP-73299.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LY75

Protein Name

lymphocyte antigen 75

Synonyms

CD205; CLEC13B; DEC-205; GP200-MR6; LY-75;

Species

Homo sapiens

Ensembl Protein

ENSP00000263636

InnateDB Gene

IDBG-73297 (LY75)

Protein Structure

UniProt Annotation

Function

Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells. {ECO:0000269PubMed:12824192, ECO:0000269PubMed:9862343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0030246	carbohydrate binding

Biological Process

GO:0006897	endocytosis
GO:0006954	inflammatory response
GO:0006955	immune response

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000562 Fibronectin, type II, collagen-binding
IPR000772 Ricin B lectin domain
IPR001304 C-type lectin
IPR013806 Kringle-like fold
IPR016187 C-type lectin fold

PFAM

PF00040
PF00652
PF14200
PF00059

PRINTS

PIRSF

SMART

SM00059
SM00458
SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60449