Version 5.4
| Homo sapiens Protein: FRMPD2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-73378.7 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | FRMPD2 | ||||||||
| Protein Name | FERM and PDZ domain containing 2 | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000307079 | ||||||||
| InnateDB Gene | IDBG-73374 (FRMPD2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). {ECO:0000269PubMed:19706687}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000305}. Basolateral cell membrane {ECO:0000269PubMed:19706687}. Cell junction, tight junction {ECO:0000269PubMed:19706687}. Note=Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in epithelial cells. {ECO:0000269PubMed:19706687}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000299
FERM domain IPR001478 PDZ domain IPR011019 KIND IPR018979 FERM, N-terminal IPR018980 FERM, C-terminal PH-like domain IPR019748 FERM central domain IPR019749 Band 4.1 domain IPR019750 Band 4.1 family IPR029071 Ubiquitin-related domain |
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| PFAM |
PF00595
PF13180 PF09379 PF09380 PF00373 |
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| PRINTS |
PR00935
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| PIRSF | |||||||||
| SMART |
SM00228
SM00750 SM00295 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q68DX3 | ||||||||
| PhosphoSite | PhosphoSite-Q68DX3 | ||||||||
| TrEMBL | F8WCT2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 728798 | ||||||||
| UniGene | Hs.723926 | ||||||||
| RefSeq | NP_001035977 | ||||||||
| HUGO | HGNC:28572 | ||||||||
| OMIM | 613323 | ||||||||
| CCDS | |||||||||
| HPRD | 17019 | ||||||||
| IMGT | |||||||||
| EMBL | AC013284 AC074325 AK123038 AK131386 AY491519 BC031614 BC073954 BC144635 BC144639 CR749241 | ||||||||
| GenPept | AAH31614 AAH73954 AAI44636 AAI44640 AAS79660 BAC85520 BAD18537 CAH18097 | ||||||||