Version 5.4
Homo sapiens Protein: ITGB6
Summary
InnateDB Protein IDBP-73391.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGB6
Protein Name integrin, beta 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000283249
InnateDB Gene IDBG-73389 (ITGB6)
Protein Structure
UniProt Annotation
Function Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. {ECO:0000269PubMed:17545607}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0004872 receptor activity
GO:0005178 integrin binding
Biological Process
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0009615 response to virus
GO:0016032 viral process
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold
PFAM PF00092
PF00362
PF07965
PF07974
PF08725
PRINTS PR01186
PIRSF PIRSF002512
SMART SM00327
SM00187
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P18564
PhosphoSite PhosphoSite-P18564
TrEMBL
UniProt Splice Variant
Entrez Gene 3694
UniGene Hs.622941
RefSeq NP_001269318
HUGO HGNC:6161
OMIM 147558
CCDS CCDS2212
HPRD 00947
IMGT
EMBL AC080166 AC092153 AK313944 BC121178 CH471058 M35198 S49380
GenPept AAA36122 AAB23690 AAI21179 AAX93093 AAY24053 BAG36662 EAX11390

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca