InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCN4B

Summary

InnateDB Protein

IDBP-73462.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN4B

Protein Name

sodium channel, voltage-gated, type IV, beta

Synonyms

ATFB17; LQT10; Navbeta4;

Species

Homo sapiens

Ensembl Protein

ENSP00000322460

InnateDB Gene

IDBG-73460 (SCN4B)

Protein Structure

UniProt Annotation

Function

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. {ECO:0000269PubMed:24297919}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:24297919}; Single-pass type I membrane protein {ECO:0000269PubMed:24297919}.

Disease Associations

Long QT syndrome 10 (LQT10) [MIM:611819]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO:0000269PubMed:17592081}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. {ECO:0000269PubMed:12930796}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential

Biological Process

GO:0006814	sodium ion transport
GO:0010765	positive regulation of sodium ion transport
GO:0035725	sodium ion transmembrane transport
GO:0060048	cardiac muscle contraction
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086067	AV node cell to bundle of His cell communication
GO:0086091	regulation of heart rate by cardiac conduction
GO:2000649	regulation of sodium ion transmembrane transporter activity