InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLL

Summary

InnateDB Protein

IDBP-73735.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLL

Protein Name

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

Synonyms

ALL-1; CXXC7; HRX; HTRX1; MLL; MLL/GAS7; MLL1; MLL1A; TET1-MLL; TRX1; WDSTS;

Species

Homo sapiens

Ensembl Protein

ENSP00000374157

InnateDB Gene

IDBG-73725 (MLL)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 143 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	143 [view]
Protein-Protein	130 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003680	AT DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044212	transcription regulatory region DNA binding
GO:0045322	unmethylated CpG binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0006915	apoptotic process
GO:0032411	positive regulation of transporter activity
GO:0035162	embryonic hemopoiesis
GO:0043984	histone H4-K16 acetylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051568	histone H3-K4 methylation
GO:0080182	histone H3-K4 trimethylation
GO:2001040	positive regulation of cellular response to drug

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0035097	histone methyltransferase complex
GO:0071339	MLL1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR001214 SET domain
IPR001487 Bromodomain
IPR001965 Zinc finger, PHD-type
IPR002857 Zinc finger, CXXC-type
IPR003616 Post-SET domain
IPR003888 FY-rich, N-terminal
IPR003889 FY-rich, C-terminal
IPR011011 Zinc finger, FYVE/PHD-type
IPR016569 Methyltransferase, trithorax
IPR019787 Zinc finger, PHD-finger

PFAM

PF00856
PF00439
PF02008
PF05964
PF05965
PF00628

PRINTS

PR00503

PIRSF

PIRSF010354

SMART

SM00317
SM00297
SM00249
SM00508
SM00541
SM00542

TIGRFAMs

Post-translational Modifications

Modification

Cross-References