Version 5.4
Homo sapiens Protein: TBPL2
Summary
InnateDB Protein IDBP-7380.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBPL2
Protein Name TATA box binding protein like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000247219
InnateDB Gene IDBG-7378 (TBPL2)
Protein Structure
UniProt Annotation
Function Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity). {ECO:0000250UniProtKB:Q6SJ95}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14634207}. Nucleus {ECO:0000269PubMed:14634207}. Note=Present in the cytoplasm during cytokenesis. {ECO:0000269PubMed:14634207}.
Disease Associations
Tissue Specificity Ubiquitously expressed in all tissues examined with highest levels in heart, lung, ovary, spleen and testes. {ECO:0000269PubMed:14634207, ECO:0000269PubMed:17570761}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0007275 multicellular organismal development
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000814 TATA-box binding protein
PFAM PF00352
PRINTS PR00686
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6SJ96
PhosphoSite PhosphoSite-Q6SJ96
TrEMBL G3V454
UniProt Splice Variant
Entrez Gene 387332
UniGene Hs.528278
RefSeq NP_950248
HUGO HGNC:19841
OMIM 608964
CCDS CCDS9724
HPRD 10607
IMGT
EMBL AL356801 AY457923 BC117159 BC117185 DQ448593
GenPept AAI17160 AAI17186 AAR24281 ABD93323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca